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Carfentanil (also known as Carfentanyl; 4-carbomethoxyfentanyl; R33799) is an analog of the synthetic opioid analgesic Fentanyl. Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included Paul Janssen.

What is Carfentanil?

Carfentanil is a Schedule II substance under the Controlled Substances Act and is used as a tranquilizing agent for elephants and other large mammals. Carfentanil is the most potent commercial opioid, according to the U.S. Drug Enforcement Agency. The lethal dose range for Carfentanil in humans is unknown, and its strong potency is a cause for great concern. Carfentanil is approximately 10,000 times more potent than morphine and 100 times more potent than Fentanyl (Fentanyl is lethal to humans in as little as 2 milligrams).

Molecular Formula: C24H30N2O3
Molecular Weight: 394.5 g/mol
Molar mass: 394.52 g/mol
CAS ID: 59708-52-0
Formula: C24H30N2O3
Elimination half-life: 7.7 hrs
Synonyms: Methoxycarbonyl-fentanyl

Carfentanil has been blamed for a spike in overdoses in Kentucky, Florida, Ohio, Pennsylvania and Canada from 2016 to early 2018, with at least 400 identified overdoses in 2017. As the Carfentanil-related overdoses continue to increase, first responders and treatment providers around the country have struggled to find solutions.

Who Uses Carfentanil?

The only DEA-approved use of Carfentanil is to sedate large zoo animals like moose, buffalo and elephants. It takes just two milligrams of Carfentanil to fully sedate a 2,000-pound African elephant. The drug is so potent and such a high risk that veterinarians who administer the drug use gloves and face masks to prevent their own exposure to it. It cannot be stressed enough that Carfentanil is not for human consumption in any way, shape or form.

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